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A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors.

Inigo Espinosa, MD a, Cheng-Han Lee, MD, PhDa, Mi Kyung Kim, MD, PhD a, Bich-Tien Rouse, MSa, Subbaya Subramanian, PhD a, Kelli Montgomery a, Sushama Varma, MS a Christopher L. Corless, MD, PhD b, Michael C. Heinrich, MD b, Kevin S. Smith, PhDa, Zhong Wang, PhDa, Brian Rubin MD, PhDc, Torsten O Nielsen MD, PhDd, Robert S Seitz MDe, Douglas T Ross, MD, PhDe , Robert B West, MD, PhDa, Michael L. Cleary, MDa, and Matt van de Rijn, MD, PhDa

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Table 1: Mesenchymal tumors other than GIST included in the study.

Tumors	Number of cases
Alveolar soft part sarcoma	2
Phyllodes tumor	2
Pleomorphic liposarcoma	3
Epithelioid sarcoma	3
Fibrosarcoma	3
Chondrosarcoma	3
Inflammatory pseudotumor	5
Clear cell sarcoma	7
DSRCT*	7
Dedifferentiated liposarcoma	10
Myxoid liposarcoma	10
Ewing/PNET	10
Desmoplastic melanoma	10
Well differentiated liposarcoma	11
Extraskeletal myxoid chondrosarcoma	11
Low grade fibromyxoid sarcoma	11
Fibroadenoma	11
Epithelioid hemangioendothelioma	12
Endometrial stroma sarcoma	13
Rhabdomyosarcoma	13
Angiosarcoma	14
Osteosarcoma	14
Dermatofibrosarcoma protuberans	20
Solitary fibrous tumor	21
Leiomyoma	22
Desmoid fibromatosis	35
Synovial sarcoma	44
Schwanoma	46
Neurofibroma	55
Malignant peripheral nerve sheath tumor	86
Undifferentiated sarcoma	87
Leiomyosarcoma	334

*Desmoplastic small round cell tumor

Table 2: Clinicopathologic features of GIST cases.

Total number of patients:

447

Age (n=341; 3-95 y;median:59)
	<18 years	9 (3%)
	≥18y <40y	31 (9%)
	≥40y <60y	139 (41%)
	≥60y	162 (48%)
Sex (n=357)
	Female	179 (50%)
	Male	178 (50%)
Size (n=303)
	≤2cm	21 (7%)
	>2cm ≤5cm	94 (31%)
	>5cm≤10cm	96 (32%)
	>10cm	92 (30%)
Location (n=337)
	Stomach	179 (53%)
	Small bowel	101 (30%)
	Large bowel	27 (8%)
	EGIST*	24 (7%)
	Esophagus	3 (1%)
	Gallbladder	3 (1%)
Risk (n=70)
	Very low	5 (7%)
	Low	30 (43%)
	Intermediate	10 (14%)
	High	25 (36%)

* Extragastrointestinal GIST.