Figure 6:

In situ hybridization of KIT, DOG1, and PDGFRA with GISTs.

  1. GIST with mutation in KIT shows positive ISH for KIT, DOG1 but not PDGFRA.
  2. GIST with mutation in PDGFRA shows positive ISH for DOG1 and PDGFRA but not for KIT.
  3. Negative control leiomyosarcoma