Figure 5:

In situ hybridization of a GIST and leiomyosarcoma with antisense probes to DOG1 and KIT on a GIST and a leiomyosarcoma (LMS).Ê The corresponding negative control sense probes are included in the inset in the upper right hand corner of the GIST sample.

  1. GIST with mutation in KIT shows positive ISH for KIT, DOG1 but not PDGFRA.
  2. GIST with mutation in PDGFRA shows positive ISH for DOG1 and PDGFRA but not for KIT.